Fioricet (Butalbital/Acetaminophen/Caffeine): Fioricet is a combination medication used to treat tension headaches. The butalbital component acts as a sedative to relax muscle contractions, acetaminophen is an analgesic that reduces pain, and caffeine helps to constrict blood vessels and increase the effectiveness of the analgesic. It is generally used when other over-the-counter pain relievers.